MICCAI '02 Proceedings of the 5th International Conference on Medical Image Computing and Computer-Assisted Intervention-Part I
Modeling glioma growth and mass effect in 3D MR images of the brain
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention - Volume Part I
Extrapolating tumor invasion margins for physiologically determined radiotherapy regions
MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
A generative approach for image-based modeling of tumor growth
IPMI'11 Proceedings of the 22nd international conference on Information processing in medical imaging
A large-scale manifold learning approach for brain tumor progression prediction
MLMI'11 Proceedings of the Second international conference on Machine learning in medical imaging
Predicting the location of glioma recurrence after a resection surgery
STIA'12 Proceedings of the Second international conference on Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data
Hi-index | 0.00 |
Gliomas are one of the most challenging tumors to treat or control locally. One of the main challenges is determining which areas of the apparently normal brain contain glioma cells, as gliomas are known to infiltrate for several centimeters beyond the clinically apparent lesion visualized on standard CT or MRI. To ensure that radiation treatment encompasses the whole tumour, including the cancerous cells not revealed by MRI, doctors treat a volume of brain extending 2cm out from the margin of the visible tumour. This expanded volume often includes healthy, non-cancerous brain tissue. Knowing that glioma cells preferentially spread along nerve fibers, we propose the use of a geodesic distance on the Riemannian manifold of brain fibers to replace the Euclidean distance used in clinical practice and to correctly identify the tumor invasion margin. To compute the geodesic distance we use actual DTI data from patients with glioma and compare our predicted growth with follow-up MRI scans. Results show improvement in predicting the invasion margin when using the geodesic distance as opposed to the 2cm conventional Euclidean distance.