An Affine Invariant Interest Point Detector
ECCV '02 Proceedings of the 7th European Conference on Computer Vision-Part I
Fast Radial Symmetry for Detecting Points of Interest
IEEE Transactions on Pattern Analysis and Machine Intelligence
ICIAP '03 Proceedings of the 12th International Conference on Image Analysis and Processing
Distinctive Image Features from Scale-Invariant Keypoints
International Journal of Computer Vision
Level Set Segmentation of Cellular Images Based on Topological Dependence
ISVC '08 Proceedings of the 4th International Symposium on Advances in Visual Computing
Identification of Cell Nucleus Using a Mumford-Shah Ellipse Detector
ISVC '08 Proceedings of the 4th International Symposium on Advances in Visual Computing
Level set methods for watershed image segmentation
SSVM'07 Proceedings of the 1st international conference on Scale space and variational methods in computer vision
Geometric approach to segmentation and protein localization in cell cultured assays
ISVC'05 Proceedings of the First international conference on Advances in Visual Computing
3D segmentation of mammospheres for localization studies
ISVC'06 Proceedings of the Second international conference on Advances in Visual Computing - Volume Part I
Combined segmentation and tracking of neural stem-cells
SCIA'05 Proceedings of the 14th Scandinavian conference on Image Analysis
Automatic Segmentation of High-Throughput RNAi Fluorescent Cellular Images
IEEE Transactions on Information Technology in Biomedicine
Self-Repelling Snakes for Topology-Preserving Segmentation Models
IEEE Transactions on Image Processing
Pattern Recognition and Image Analysis
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Neural stem cells derived from both embryonic and adult brain can be cultured as neurospheres; a free floating 3-D aggregate of cells. Neurospheres represent a heterogenous mix of cells including neural stem and progenitor cells. In order to investigate the self-renewal, growth and differentiation of cells within neurospheres, it is crucial that individual nuclei are accurately identified using image segmentation. Hence effective segmentation algorithm is indispensible for microscopy based neural stem cell studies. In this paper, we present a seed finding approach in scale space to identify the center of nuclei in 3-D. Then we present a novel segmentation approach, called "Evolving Generalized Voronoi Diagram", which uses the identified centers to segment nuclei in neurospheres. Comparison of our computational results to mannually annotated ground truth demonstrates that the proposed approach is an efficient and accurate segmentation approach for 3-D neurospheres.