Atlas-based registration parameters in segmenting sub-cortical regions from brain MRI-images

  • Authors:
  • Jyrki Lötjönen;Juha Koikkalainen;Lennart Thurfjell;Daniel Rueckert

  • Affiliations:
  • VTT Technical Research Centre of Finland, Tampere, Finland;VTT Technical Research Centre of Finland, Tampere, Finland;GE Healthcare, Medical Diagnostics R&D, Uppsala, Sweden;Imperial College London, London, UK

  • Venue:
  • ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
  • Year:
  • 2009

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Abstract

Multi-atlas segmentation has been proved to perform well in segmenting sub-cortical structures from images. In this work, we study different components of multi-atlas segmentation and propose new techniques to improve the segmentation accuracy. We found that the use of gradient information in addition to standard normalised mutual information increases the registration accuracy. We also studied different techniques to select atlases in the multi-atlas segmentation. In addition, the expectation maximisation algorithm was used to combinemulti-atlas and intensity model information. The average similarity index obtained for six subcortical structures was 0.84.