Quantitative evaluation of virtual angiography for interventional X-ray acquisitions

Authors:
Qi Sun;Alexandra Groth;Irina Waechter;Olivier Brina;Jürgen Weese;Til Aach
Affiliations:
Philips Research Europe, Aachen, Germany and Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany;Philips Research Europe, Aachen, Germany;Philips Research Europe, Aachen, Germany;University Hospital of Geneva, Department of Neuroradiology, Switzerland;Philips Research Europe, Aachen, Germany;Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany
Venue:
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Year:
2009

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Abstract

Virtual angiography has been recently proposed [1] as a method to indirectly validate the accuracy of computational fluid dynamic (CFD) simulations. In doing so, X-ray angiograms are created from CFD results and compared with the acquired data. In this paper, we apply the extended virtual angiography method [2] which has been only tested on an imaged phantom to clinical data for the first time. To obtain realistic CFD simulations, the contrast agent injection (CA) curve and patient specific blood flow measured by transcranial colour coded Doppler ultrasound (TCCD) are used as boundary conditions. In a quantitative comparison, the spatial and temporal variation of CA concentration of both clinical and virtual angiograms showed good correspondence.