Automatically learning cortical folding patterns

  • Authors:
  • Matthew Toews;D. Louis Collins;Tal Arbel

  • Affiliations:
  • Centre for Intelligent Machines, McGill University;Montreal Neurological Institute, McGill University;Centre for Intelligent Machines, McGill University

  • Venue:
  • ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
  • Year:
  • 2009

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Abstract

A data-driven technique is presented for automatically learning cortical folding patterns from MR brain images of different subjects. Cortical patterns are represented in terms of generic scale-invariant image features. Learning automatically identifies a set of features that occur with statistical regularity in appearance and geometry from a large set of MR volume renderings, based on a predescribed anatomical region of interest. A filtering technique is presented for distinguishing between valid cortical features and those likely to arise from incorrect correspondences, based on feature geometry. Expert validation of 100 feature instances shows that 77% correctly identify the same underlying cortical structure in different brains despite high inter-subject variability, and filtering improves the ability to identify the most meaningful patterns.