Introduction to artificial neural systems
Introduction to artificial neural systems
Essentials of fuzzy modeling and control
Essentials of fuzzy modeling and control
Fuzzy neural network in case-based diagnostic system
IEEE Transactions on Fuzzy Systems
Approximation accuracy of some neuro-fuzzy approaches
IEEE Transactions on Fuzzy Systems
Potential improvement of classifier accuracy by using fuzzy measures
IEEE Transactions on Fuzzy Systems
Taking on the curse of dimensionality in joint distributions using neural networks
IEEE Transactions on Neural Networks
Expert Systems with Applications: An International Journal
Optimizing back-propagation networks via a calibrated heuristic algorithm with an orthogonal array
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Automated trend analysis of proteomics data using an intelligent data mining architecture
Expert Systems with Applications: An International Journal
Hi-index | 12.06 |
The aim of the study was to create simple, neural model of ketoprofen (Ket) dissolution from solid dispersions (SD) and physical mixtures (PM), which could be an aid in prospective development of pharmaceutical formulation. An application of artificial neural networks (ANNs) methodology was investigated using experimental data. Backpropagation (BP) ANNs with two hidden layers, hyperbolic tangent as the activation function and Hampel's target function were studied. Neuro-fuzzy systems were also applied. As the input variables formulation type and preparation technology as well as qualitative and quantitative composition of SD and physical mixtures (PM) were selected. Direct incorporation of physicochemical properties of excipients (connectivity index, CI) enhanced ANNs model usability. Further improvement of neural model was achieved by input variables reduction performed on the basis of the sensitivity analysis. ANNs functions as decision support system in prospective ketoprofen SD formulation as well as data-mining tool were confirmed.