Computers and Operations Research
RECOMB '01 Proceedings of the fifth annual international conference on Computational biology
Finding the consensus shape for a protein family
Proceedings of the eighteenth annual symposium on Computational geometry
Structural alignment of large—size proteins via lagrangian relaxation
Proceedings of the sixth annual international conference on Computational biology
Alignment Of Protein Structures With A Memetic Evolutionary Algorithm
GECCO '02 Proceedings of the Genetic and Evolutionary Computation Conference
Algorithmic Aspects of Protein Structure Similarity
FOCS '99 Proceedings of the 40th Annual Symposium on Foundations of Computer Science
Self Generating Metaheuristics in Bioinformatics: The Proteins Structure Comparison Case
Genetic Programming and Evolvable Machines
Search spaces representation in optimization problems
Expert Systems with Applications: An International Journal
A framework for developing optimization-based decision support systems
Expert Systems with Applications: An International Journal
Natural computing methods in bioinformatics: A survey
Information Fusion
Proceedings of the 2007 conference on Emerging Artificial Intelligence Applications in Computer Engineering: Real Word AI Systems with Applications in eHealth, HCI, Information Retrieval and Pervasive Technologies
IPDPS'06 Proceedings of the 20th international conference on Parallel and distributed processing
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The comparison of protein structures is an important problem in bioinformatics. As a protein biological role is derived from its three-dimensional native state, the comparison of a new protein structure (with unknown function) with other protein structures (with known biological activity) can shed light into the biological role of the former. Consequently, advances in the comparison (and clustering) of proteins according to their three-dimensional configurations might also have an impact on drug discovery and other biomedical research that relies on understanding the inter-relations between structure and function in proteins. The contributions described in this paper are: Firstly, we propose a generalization of the maximum contact map overlap problem (MAX-CMO) by means of fuzzy sets and systems. The MAX-CMO is a model for protein structure comparison. In our new model, namedgeneralized maximum fuzzy contact map overlap (GMAX-FCMO), a contact map is defined by means of one (or more) fuzzy thresholds and one (or more) membership functions. The advantages and limitations of our new model are discussed. Secondly, we show how a fuzzy sets based metaheuristic can be used to compute protein similarities based on the new model. Finally, we compute the protein structure similarity of real-world proteins and show how our new model correctly measures their (di)similarity.