An integrated model for visualizing biclusters from gene expression data and PPI networks

Authors:
Ahmet Emre Aladağ;Cesim Erten;Melih Sözdinler
Affiliations:
Kadir Has University, Istanbul, Turkey;Kadir Has University, Istanbul, Turkey;Boğaziçi University, Istanbul, Turkey
Venue:
ISB '10 Proceedings of the International Symposium on Biocomputing
Year:
2010

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Abstract

We provide a model to integrate the visualization of biclusters extracted from gene expresion data and the underlying PPI networks. Such an integration conveys the biologically relevant interconnection between these two structures inferred from biological experiments. We model the reliabilities of the structures using directed graphs with vertex and edge weights. The resulting graphs are drawn using appropriate weighted modifications of the algorithms necessary for the layered drawings of directed graphs. We provide applications of the proposed visualization model on the S. cerevisiae dataset.