Switch detection in genetic regulatory networks

Authors:
Riccardo Porreca;Giancarlo Ferrari-Trecate;Daniela Chieppi;Lalo Magni;Olivier Bernard
Affiliations:
Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy;Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy;INRIA, Sophia Antipolis, Sophia Antipolis, France
Venue:
HSCC'07 Proceedings of the 10th international conference on Hybrid systems: computation and control
Year:
2007

Citing 2
Cited 0

Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks

HSCC'06 Proceedings of the 9th international conference on Hybrid Systems: computation and control
Comparison of four procedures for the identification of hybrid systems

HSCC'05 Proceedings of the 8th international conference on Hybrid Systems: computation and control

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Abstract

This paper considers piecewise affine models of genetic regulatory networks and focuses on the problem of detecting switches among different modes of operation in gene expression data. This task constitutes the first step of a procedure for the complete identification of the network. We propose two methods and illustrate the application to the reconstruction of switching times in data produced by a piecewise affine model of the network regulating the carbon starvation response in Escherichia coli.