Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks

Authors:
S. Drulhe;G. Ferrari-Trecate;H. de Jong;A. Viari
Affiliations:
INRIA Rhône-Alpes, Montbonnot, Saint Ismier, France;INRIA, Rocquencourt, Le Chesnay, France;INRIA Rhône-Alpes, Montbonnot, Saint Ismier, France;INRIA Rhône-Alpes, Montbonnot, Saint Ismier, France
Venue:
HSCC'06 Proceedings of the 9th international conference on Hybrid Systems: computation and control
Year:
2006

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Abstract

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.