Qualitative reasoning: modeling and simulation with incomplete knowledge
Qualitative reasoning: modeling and simulation with incomplete knowledge
A comprehensive methodology for building hybrid models of physical systems
Artificial Intelligence
Qualitative simulation of genetic regulatory networks: method and application
IJCAI'01 Proceedings of the 17th international joint conference on Artificial intelligence - Volume 1
Modeling Cellular Behavior with Hybrid Automata: Bisimulation and Collapsing
CMSB '03 Proceedings of the First International Workshop on Computational Methods in Systems Biology
Applications of finite fields to dynamical systems and reverse engineering problems
Proceedings of the 2004 ACM symposium on Applied computing
Proceedings of the 38th conference on Winter simulation
Parallel Model Checking Large-Scale Genetic Regulatory Networks with DiVinE
Electronic Notes in Theoretical Computer Science (ENTCS)
Local Identification of Piecewise Deterministic Models of Genetic Networks
HSCC '09 Proceedings of the 12th International Conference on Hybrid Systems: Computation and Control
Learning cycle-linear hybrid automata for excitable cells
HSCC'07 Proceedings of the 10th international conference on Hybrid systems: computation and control
Evolution and analysis of a robot controller based on a gene regulatory network
ICES'10 Proceedings of the 9th international conference on Evolvable systems: from biology to hardware
On oscillations damping and control for a class of affine systems
GAVTASC'11 Proceedings of the 11th WSEAS international conference on Signal processing, computational geometry and artificial vision, and Proceedings of the 11th WSEAS international conference on Systems theory and scientific computation
HSCC'05 Proceedings of the 8th international conference on Hybrid Systems: computation and control
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
The Regulatory Network Computational Device
Genetic Programming and Evolvable Machines
Genetic programming with genetic regulatory networks: genetic programming
Proceedings of the 15th annual conference on Genetic and evolutionary computation
GEARNet: grammatical evolution with artificial regulatory networks
Proceedings of the 15th annual conference on Genetic and evolutionary computation
Hi-index | 0.00 |
The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes. We present a method for the hybrid modeling and simulation of genetic regulatory networks, based on a class of piecewise-linear (PL) differential equations that has been well-studied in mathematical biology. Distinguishing characteristics of the method are that it makes qualitative predictions of the behavior of regulatory systems and that it deals with discontinuities in the right-hand side of the differential equations. The simulation method has been implemented in Java in the computer tool Genetic Network Analyzer (GNA). The method and the tool have been used to analyze several networks of biological interest, including the network underlying the initiation of sporulation in Bacillus subtilis.