Qualitative simulation of genetic regulatory networks: method and application

Authors:
Hidde De Jong;Michel Page;Cane Hernandez;Johannes Geiselmann
Affiliations:
INRIA Rhône, Saint Ismier Cedex, France;INRIA Rhône, Saint Ismier Cedex, France and ESA, Université Pierre Mendès France , Grenoble;INRIA Rhône, Saint Ismier Cedex, France;PEGM, Universite joseph Fourier, Grenoble, France
Venue:
IJCAI'01 Proceedings of the 17th international joint conference on Artificial intelligence - Volume 1
Year:
2001

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Abstract

Computer modeling and simulation are indispensable for understanding the functioning of an organism on a molecular level. We present an implemented method for the qualitative simulation of large and complex genetic regulatory networks. The method allows a broad range of regulatory interactions between genes to be represented and has been applied to the analysis of a real network of biological interest, the network controlling the inititation of sporulation in the bacterium B. subtilis.