CMSB '03 Proceedings of the First International Workshop on Computational Methods in Systems Biology
RSP '03 Proceedings of the 14th IEEE International Workshop on Rapid System Prototyping (RSP'03)
Fixed points and maximal independent sets in AND-OR networks
Discrete Applied Mathematics
Qualitative simulation of genetic regulatory networks: method and application
IJCAI'01 Proceedings of the 17th international joint conference on Artificial intelligence - Volume 1
A unifying framework for modelling and analysing biochemical pathways using Petri nets
CMSB'07 Proceedings of the 2007 international conference on Computational methods in systems biology
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The main contribution of this work is a mathematical theorem which establishes a necessary and sufficient condition to preserve the behaviour of a genetic regulatory network when it is embedded into a larger network. We adopt the modelling approach of René Thomas, which provides a discrete representation of biological regulatory networks. This framework is entirely formalized using labelled graphs with semantics defined in terms of state graphs with transitions. Our theorem offers the possibility to automatically verify whether a subnetwork has autonomous behaviour. It will allow biologists to better identify relevant sets of genes which should be studied together.