Ensemble of dissimilarity based classifiers for cancerous samples classification

Authors:
Angela Blanco;Manuel Martín-Merino;Javier De Las Rivas
Affiliations:
Universidad Pontificia de Salamanca, Salamanca, Spain;Universidad Pontificia de Salamanca, Salamanca, Spain;Cancer Research Center of Salamanca, Salamanca, Spain
Venue:
PRIB'07 Proceedings of the 2nd IAPR international conference on Pattern recognition in bioinformatics
Year:
2007

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Abstract

DNA Microarray technology allow us to identify cancerous tissues considering the gene expression levels across a collection of related samples. Several classifiers such as Support Vector Machines (SVM), k Nearest Neighbors (k-NN) or Diagonal Linear Discriminant Analysis (DLDA) have been applied to this problem. However, they are usually based on Euclidean distances that fail to reflect accurately the sample proximities. Several classifiers have been extended to work with non-Euclidean dissimilarities although none outperforms the others because they misclassify a different set of patterns. In this paper, we combine different kind of dissimilarity based classifiers to reduce the misclassification errors. The diversity among classifiers is induced considering a set of complementary dissimilarities for three different type of models. The experimental results suggest that the algorithm proposed helps to improve classifiers based on a single dissimilarity and a widely used combination strategy such as Bagging.