Chaos-differential evolution for multiple sequence alignment

  • Authors:
  • Gui-wu Hu

  • Affiliations:
  • School of Mathematics & Computational Science, Guangdong University of Business Studies, Guangzhou, China

  • Venue:
  • IITA'09 Proceedings of the 3rd international conference on Intelligent information technology application
  • Year:
  • 2009

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Abstract

Multiple Sequence Alignment is one of the most important and challenging problem in bioinformatics, which is known as NP-hard problem. In this paper, a Chaos-differential evolution (CDE) is proposed to solve MSA. In the proposed CDE algorithm, DE and chaos are hybridized to combine the evolutionary searching ability of DE and overcoming local optima of chaotic local search. Simulation shows that novel algorithm has superior performance compared to other existing algorithms.