The nature of statistical learning theory
The nature of statistical learning theory
Gene expression profile class prediction using linear Bayesian classifiers
Computers in Biology and Medicine
Brief communication: Reducing multiclass cancer classification to binary by output coding and SVM
Computational Biology and Chemistry
Gene feature extraction using T-test statistics and kernel partial least squares
ICONIP'06 Proceedings of the 13th international conference on Neural information processing - Volume Part III
Local linear logistic discriminant analysis with partial least square components
ADMA'06 Proceedings of the Second international conference on Advanced Data Mining and Applications
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In order to deal with the interaction between genes effectively, a kernel technology was adopted into a subspace method in our study. A linear subspace classifier was generalized to a nonlinear kernel subspace classifier by using a kernel principle component analysis method to constitute nonlinear feature subspaces. Because DNA microarray data have characteristics of high dimension, few samples and strong nonlinearity, three types of classifiers based on kernel machine learning method were designed, i.e., support vector machine (SVM), kernel subspace classifier (KSUB-C) and kernel partial least-squares discriminant analysis (KPLS-DA). But the performances of these classifiers lie on the optimum setting of kernel functions and parameters. Therefore, to avoid the difficulty of selecting optimal kernel functions and parameters and to further improve the accuracy and generalization property of the classifiers, an ensemble classifier based on kernel method for multi-situation DNA microarray data was proposed by adopting the idea of ensemble learning. The ensemble classifier combines the classification results of the SVM, KSUB-C and KPLS-DA classifiers. Experimental results involving three public DNA microarray datasets indicate that the proposed ensemble classifier has high classification accuracy and perfect generalization property.