A study of cross-validation and bootstrap for accuracy estimation and model selection
IJCAI'95 Proceedings of the 14th international joint conference on Artificial intelligence - Volume 2
Computer Methods and Programs in Biomedicine
New gene selection method for multiclass tumor classification by class centroid
Journal of Biomedical Informatics
Genome-based identification of diagnostic molecular markers for human lung carcinomas by PLS-DA
Computational Biology and Chemistry
Computational Biology and Chemistry
Exploiting scale-free information from expression data for cancer classification
Computational Biology and Chemistry
IJCNN'09 Proceedings of the 2009 international joint conference on Neural Networks
An ensemble classifier based on kernel method for multi-situation DNA microarray data
ICIC'09 Proceedings of the 5th international conference on Emerging intelligent computing technology and applications
DifFUZZY: a fuzzy clustering algorithm for complex datasets
International Journal of Computational Intelligence in Bioinformatics and Systems Biology
Estrogen receptor status prediction by gene component regression: a comparative study
International Journal of Data Mining and Bioinformatics
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High-throughput DNA microarray provides an effective approach to the monitoring of expression levels of thousands of genes in a sample simultaneously. One promising application of this technology is the molecular diagnostics of cancer, e.g. to distinguish normal tissue from tumor or to classify tumors into different types or subtypes. One problem arising from the use of microarray data is how to analyze the high-dimensional gene expression data, typically with thousands of variables (genes) and much fewer observations (samples). There is a need to develop reliable classification methods to make full use of microarray data and to evaluate accurately the predictive ability and reliability of such derived models. In this paper, discriminant partial least squares was used to classify the different types of human tumors using four microarray datasets and showed good prediction performance. Four different cross-validation procedures (leave-one-out versus leave-half-out; incomplete versus full) were used to evaluate the classification model. Our results indicate that discriminant partial least squares using leave-half-out cross-validation provides a more realistic estimate of the predictive ability of a classification model, which may be overestimated by some of the cross-validation procedures, and the information obtained from different cross-validation procedures can be used to evaluate the reliability of the classification model.