Protein structure prediction on a lattice model via multimodal optimization techniques

  • Authors:
  • Ka-Chun Wong;Kwong-Sak Leung;Man-Hon Wong

  • Affiliations:
  • The Chinese University of Hong Kong, Hong Kong, Hong Kong;The Chinese University of Hong Kong, Hong Kong, Hong Kong;The Chinese University of Hong Kong, Hong Kong, Hong Kong

  • Venue:
  • Proceedings of the 12th annual conference on Genetic and evolutionary computation
  • Year:
  • 2010

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Abstract

This paper considers the protein structure prediction problem as a multimodal optimization problem. In particular, de novo protein structure prediction problems on the 3D Hydrophobic-Polar (HP) lattice model are tackled by evolutionary algorithms using multimodal optimization techniques. In addition, a new mutation approach and performance metric are proposed for the problem. The experimental results indicate that the proposed algorithms are more effective than the state-of-the-arts algorithms, even though they are simple.