Graph-based multi-resolution segmentation of histological whole slide images

  • Authors:
  • V. Roullier;V-T. Ta;O. Lézoray;A. Elmoataz

  • Affiliations:
  • Université de Caen Basse-Nonnandie, Caen Cedex, France;Université de Caen Basse-Nonnandie, Caen Cedex, France;Université de Caen Basse-Nonnandie, Caen Cedex, France;Université de Caen Basse-Nonnandie, Caen Cedex, France

  • Venue:
  • ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
  • Year:
  • 2010

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Abstract

In this paper, we present a graph-based multi-resolution approach for mitosis extraction in breast cancer histological whole slide images. The proposed segmentation uses a multiresolution approach which reproduces the slide examination done by a pathologist. Each resolution level is analyzed with a focus of attention resulting from a coarser resolution level analysis. At each resolution level, a spatial refinement by semi-supervised clustering is performed to obtain more accurate segmentation around edges. The proposed segmentation is fully unsupervised by using domain specific knowledge.