A Newborn Screening System Based on Service-Oriented Architecture Embedded Support Vector Machine

Authors:
Kai-Ping Hsu;Sung-Huai Hsieh;Sheau-Ling Hsieh;Po-Hsun Cheng;Yung-Ching Weng;Jang-Hung Wu;Feipei Lai
Affiliations:
Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan;Information Systems Office, National Taiwan University Hospital, Taipei, Taiwan and Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan;Information Systems Office, National Taiwan University Hospital, Taipei, Taiwan and Network and Computer Centre, National Chiao Tung University, Hsin Chu, Taiwan;Software Engineering Department, National Kaohsiung Normal University, Kaohsiung, Taiwan;Information Systems Office, National Taiwan University Hospital, Taipei, Taiwan and Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan;Network and Computer Centre, National Chiao Tung University, Hsin Chu, Taiwan;Information Systems Office, National Taiwan University Hospital, Taipei, Taiwan and Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan and Depar ...
Venue:
Journal of Medical Systems
Year:
2010

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Abstract

The clinical symptoms of metabolic disorders are rarely apparent during the neonatal period, and if they are not treated earlier, irreversible damages, such as mental retardation or even death, may occur. Therefore, the practice of newborn screening is essential to prevent permanent disabilities in newborns. In the paper, we design, implement a newborn screening system using Support Vector Machine (SVM) classifications. By evaluating metabolic substances data collected from tandem mass spectrometry (MS/MS), we can interpret and determine whether a newborn has a metabolic disorder. In addition, National Taiwan University Hospital Information System (NTUHIS) has been developed and implemented to integrate heterogeneous platforms, protocols, databases as well as applications. To expedite adapting the diversities, we deploy Service-Oriented Architecture (SOA) concepts to the newborn screening system based on web services. The system can be embedded seamlessly into NTUHIS.