Active shape models—their training and application
Computer Vision and Image Understanding
MICCAI '02 Proceedings of the 5th International Conference on Medical Image Computing and Computer-Assisted Intervention-Part I
MR to Ultrasound Image Registration for Guiding Prostate Biopsy and Interventions
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part I
Design and preliminary accuracy studies of an MRI-guided transrectal prostate intervention system
MICCAI'07 Proceedings of the 10th international conference on Medical image computing and computer-assisted intervention
MR prior based automatic segmentation of the prostate in TRUS images for MR/TRUS data fusion
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Required accuracy of MR-US registration for prostate biopsies
MICCAI'11 Proceedings of the 2011 international conference on Prostate cancer imaging: image analysis and image-guided interventions
MICCAI'11 Proceedings of the 2011 international conference on Prostate cancer imaging: image analysis and image-guided interventions
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In this paper, a system for fusion of realtime transrectal ultrasound (TRUS) with pre-acquired 3D images of the prostate is presented with a clinical demonstration on a cohort of 101 patients with suspicion of prostate cancer. Electromagnetically tracked biopsy guides for endocavity ultrasound transducers were calibrated and used to fuse MRI-based suspicious lesion locations with ultrasound image coordinates. The prostate shape is segmented from MRI in a semi-automated fashion via a model-based approach, and intraoperative image registration is performed between MR and ultrasound image space to superimpose target fiducials markers on the ultrasound image. In order to align both modalities, a surface model is automatically extracted from 2D swept TRUS images using a partial active shape model, utilizing image features and prior statistics. An automatic prostate motion compensation algorithm can be triggered as needed. The results were used to display live TRUS images fused with spatially corresponding realtime multiplanar reconstructions (MPRs) of the MR image volume. In this study, all patients were scanned with 3T MRI and TRUS for biopsy. Clinical results show significant improvement of target visualization and of positive detection rates during TRUS-guided biopsies. It also demonstrates the feasibility of realtime MR/TRUS image fusion for out-of-gantry procedures.