BAT: a new biclustering analysis toolbox

  • Authors:
  • Cristian Andrés Gallo;Julieta Sol Dussaut;Jessica Andrea Carballido;Ignacio Ponzoni

  • Affiliations:
  • Laboratorio de Investigación y Desarrollo en Computación Científica, Departamento de Ciencias e Ingeniería de la Computación, Universidad Nacional del Sur, Bahía Blan ...;Laboratorio de Investigación y Desarrollo en Computación Científica, Departamento de Ciencias e Ingeniería de la Computación, Universidad Nacional del Sur, Bahía Blan ...;Laboratorio de Investigación y Desarrollo en Computación Científica, Departamento de Ciencias e Ingeniería de la Computación, Universidad Nacional del Sur, Bahía Blan ...;Lab. de Investigación y Desarrollo en Computación Científica, Dept. de Ciencias e Ingeniería de la Computación, Univ. Nacional del Sur, Bahía, Argentina and Planta Pi ...

  • Venue:
  • BSB'10 Proceedings of the Advances in bioinformatics and computational biology, and 5th Brazilian conference on Bioinformatics
  • Year:
  • 2010

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Abstract

In this paper, a new biclustering analysis toolbox called BAT, which is based on the BiHEA (Biclustering via a Hybrid Evolutionary Algorithm), is presented. The BiHEA is a memetic approach that integrates a Multi-Objective Evolutionary Algorithm (MOEA) with a local search technique in order to perform microarray biclustering. This method simultaneously considers several goals for optimization, giving as a result a set of biclusters that present a satisfactory trade-off between all of them. The novel software introduced in this article provides the possibility of running the BiHEA along with several pre-processing facilities for the input data and different visualization and statistical tools for the analysis of the biclusters.