Multi-objective evolutionary biclustering of gene expression data

  • Authors:
  • Sushmita Mitra;Haider Banka

  • Affiliations:
  • Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700 108, India;Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700 108, India

  • Venue:
  • Pattern Recognition
  • Year:
  • 2006

Quantified Score

Hi-index 0.01

Visualization

Abstract

Biclustering or simultaneous clustering of both genes and conditions have generated considerable interest over the past few decades, particularly related to the analysis of high-dimensional gene expression data in information retrieval, knowledge discovery, and data mining. The objective is to find sub-matrices, i.e., maximal subgroups of genes and subgroups of conditions where the genes exhibit highly correlated activities over a range of conditions. Since these two objectives are mutually conflicting, they become suitable candidates for multi-objective modeling. In this study, a novel multi-objective evolutionary biclustering framework is introduced by incorporating local search strategies. A new quantitative measure to evaluate the goodness of the biclusters is developed. The experimental results on benchmark datasets demonstrate better performance as compared to existing algorithms available in literature.