Mining Deterministic Biclusters in Gene Expression Data

  • Authors:
  • Affiliations:
  • Venue:
  • BIBE '04 Proceedings of the 4th IEEE Symposium on Bioinformatics and Bioengineering
  • Year:
  • 2004

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Abstract

A bicluster of a gene expression dataset captures thecoherence of a subset of genes and a subset of conditions.Biclustering algorithms are used to discoverbiclusters whose subset of genes are co-regulated undersubset of conditions. In this paper, we present anovel approach, called DBF (Deterministic Biclusteringwith Frequent pattern mining) to finding biclusters.Our scheme comprises two phases. In the first phase, wegenerate a set of good quality biclusters based on frequentpattern mining. In the second phase, the biclustersare further iteratively refined (enlarged) by addingmore genes and/or conditions. We evaluated our schemeagainst FLOC and our results show that DBF can generatelarger and better biclusters.