Biclusters evaluation based on shifting and scaling patterns

  • Authors:
  • Juan A. Nepomuceno;Alicia Troncoso Lora;Jesús S. Aguilar-Ruiz;Jorge García-Gutiérrez

  • Affiliations:
  • Department of Computer Science, University of Sevilla, Sevilla, Spain;Area of Computer Science, School of Engineering, Pablo de Olavide University, Sevilla, Spain;Area of Computer Science, School of Engineering, Pablo de Olavide University, Sevilla, Spain;Department of Computer Science, University of Sevilla, Sevilla, Spain

  • Venue:
  • IDEAL'07 Proceedings of the 8th international conference on Intelligent data engineering and automated learning
  • Year:
  • 2007

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Abstract

Microarray techniques have motivated the develop of different methods to extract useful information from a biological point of view. Biclustering algorithms obtain a set of genes with the same behaviour over a group of experimental conditions from gene expression data. In order to evaluate the quality of a bicluster, it is useful to identify specific tendencies represented by patterns on data. These patterns describe the behaviour of a bicluster obtained previously by an adequate biclustering technique from gene expression data. In this paper a new measure for evaluating biclusters is proposed. This measure captures a special kind of patterns with scaling trends which represents quality patterns. They are not contemplated with the previous evaluating measure accepted in the literature. This work is a first step to investigate methods that search biclusters based on the concept of shift and scale invariance. Experimental results based on the yeast cell cycle and the human B-cell lymphoma datasets are reported. Finally, the performance of the proposed technique is compared with an optimization method based on the Nelder-Mead Simplex search algorithm.