Evolutionary fuzzy biclustering of gene expression data

Authors:
Sushmita Mitra;Haider Banka;Jiaul Hoque Paik
Affiliations:
Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India;Centre for Soft Computing Research, Indian Statistical Institute, Kolkata, India;Machine Intelligence Unit, Indian Statistical Institute, Kolkata, India
Venue:
RSKT'07 Proceedings of the 2nd international conference on Rough sets and knowledge technology
Year:
2007

Citing 7
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Abstract

Biclustering or simultaneous clustering attempts to find maximal subgroups of genes and subgroups of conditions where the genes exhibit highly correlated activities over a range of conditions. The possibilistic approach extracts one bicluster at a time, by assigning to it a membership for each gene-condition pair. In this study, a novel evolutionary framework is introduced for generating optimal fuzzy possibilistic biclusters from microarray gene expression data. The different parameters controlling the size of the biclusters are tuned. The experimental results on benchmark datasets demonstrate better performance as compared to existing algorithms available in literature.