In vivo MRI assessment of knee cartilage in the medial meniscal tear model of osteoarthritis in rats

Authors:
Zhiyong Xie;Serguei Liachenko;Ping-Chun Chiao;Santos Carvajal-Gonzalez;Susan Bove;Thomas Bocan
Affiliations:
Pfizer Inc, Groton, CT;NCTR, FDA, Jefferson, AR;Pfizer Inc, Groton, CT;Pfizer Inc, Groton, CT;Pfizer Inc, Groton, CT;Pfizer Inc, Groton, CT
Venue:
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part III
Year:
2010

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Abstract

We present a new approach for quantifying the degradation of knee cartilage in the medial meniscal tear (MMT) model of osteoarthritis in the rat. A statistical strategy was used to guide the selection of a region of interest (ROI) from the images obtained from a pilot study. We hypothesize that this strategy can be used to localize a region of cartilage most vulnerable to MMT-induced damage. In order to test this hypothesis, a longitudinal study was conducted in which knee cartilage thickness in a pre-selected ROI was monitored for three weeks and comparisons were made between MMT and control rats. We observed a significant decrease in cartilage thickness in MMT rats and a significant increase in cartilage thickness in sham-operated rats as early as one week post surgery when compared to pre-surgery measurements.