An object-oriented library for systematic training and comparison of classifiers for computer-assisted tumor diagnosis from MRSI measurements

Authors:
Frederik O. Kaster;Bernd Merkel;Oliver Nix;Fred A. Hamprecht
Affiliations:
Heidelberg Collaboratory for Image Processing, University of Heidelberg, Heidelberg, Germany 69115 and German Cancer Research Center, Heidelberg, Germany 69120;Fraunhofer MeVis Institute for Medical Image Computing, Bremen, Germany 28359;German Cancer Research Center, Heidelberg, Germany 69120;Heidelberg Collaboratory for Image Processing, University of Heidelberg, Heidelberg, Germany 69115
Venue:
Computer Science - Research and Development
Year:
2011

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Abstract

We present an object-oriented library for the systematic training, testing and benchmarking of classification algorithms for computer-assisted diagnosis tasks, with a focus on tumor probability estimation from magnetic resonance spectroscopy imaging (MRSI) measurements. In connection with a graphical user interface for data annotation, it allows clinical end users to flexibly adapt these classifiers towards changed classification tasks, to benchmark various classifiers and preprocessing steps and to perform quality control of the results. This poses an advantage over previous classification software solutions, which required expert knowledge in pattern recognition techniques in order to adapt them to changes in the data acquisition protocols. This software will constitute a major part of the MRSI analysis functionality of RONDO, an integrated software platform for cancer diagnosis and therapy planning which is under current development.