Gene expression network discovery: a pattern based biclustering approach

  • Authors:
  • Debahuti Mishra;Kailash Shaw;Sashikala Mishra;Amiya Kumar Rath;Milu Acharya

  • Affiliations:
  • Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India;Gandhi Engineering College, Bhubaneswar, Odisha, India;Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India;College of Engineering Bhubaneswar, Bhubaneswar, Odisha, India;Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India

  • Venue:
  • Proceedings of the 2011 International Conference on Communication, Computing & Security
  • Year:
  • 2011

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Abstract

Discovering biologically significant information from gene expression data is now a days playing important role in gene function detection, gene regulation, drug discovery, detecting and predicting the diseases. Many traditional clustering algorithms are present to discover such gene regulations. Such discovered clusters are known as global clusters, which incurs more processing overhead. To overcome such problem, the biclustering approach, also known as local clustering has been emerged. Generally, there are two ways of measuring the similarity among subset of objects and attributes. First one is grouping the data elements by measuring the similarity based on the proximity. But, there may be the case that, many objects and attributes which are far apart but the gives significant meaning for being grouped. This problem can be solved by the second method, which not only measures the proximity of data elements but also find subset of objects and attributes which forms similar or coherent patterns such as scaling and shifting irrespective of their proximity. In this paper, we have implemented the pattern based clustering and before that the dimensionality reduction using Principal Component Analysis (PCA) is used to reduce the attributes without loss of information. We have compared the Minimum Squared Residue (MSR) approach of Cheng and Church with our proposed model. Our method shows its better performance as compared to MSR based approach.