Multi-physics MRI-based two-layer fluid-structure interaction anisotropic models of human right and left ventricles with different patch materials: Cardiac function assessment and mechanical stress analysis

Authors:
Dalin Tang;Chun Yang;Tal Geva;Glenn Gaudette;Pedro J. del Nido
Affiliations:
Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA;Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA and School of Mathematics, Beijing Normal University, Beijing, China;Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA;Department of Cardiac Surgery, Children's Hospital Boston, Boston, MA 02115, USA and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
Venue:
Computers and Structures
Year:
2011

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Abstract

Multi-physics right and left ventricle (RV/LV) fluid-structure interaction (FSI) models were introduced to perform mechanical stress analysis and evaluate the effect of patch materials on RV function. The FSI models included three different patch materials (Dacron scaffold, treated pericardium, and contracting myocardium), two-layer construction, fiber orientation, and active anisotropic material properties. The models were constructed based on cardiac magnetic resonance (CMR) images acquired from a patient with severe RV dilatation and solved by ADINA. Our results indicate that the patch model with contracting myocardium leads to decreased stress level in the patch area, improved RV function and patch area contractility.