A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction

  • Authors:
  • Dalin Tang;Chun Yang;Tal Geva;Rahul Rathod;Haruo Yamauchi;Vasu Gooty;Alexander Tang;Mehmet H. Kural;Kristen L. Billiar;Glenn Gaudette;Pedro J. Del Nido

  • Affiliations:
  • School of Biological Science and Medical Engineering, Southeast University, Nanjing, China and Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, United States;Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, United States and School of Mathematical Sciences, Beijing Normal University, Key Laboratory of Mathematics ...;Department of Cardiology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;Department of Cardiology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;Department of Cardiac Surgery, Children's Hospital Boston, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA;Department of Cardiology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;Department of Cardiology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA;Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA and Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, United States;Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA;Department of Cardiac Surgery, Children's Hospital Boston, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA

  • Venue:
  • Computers and Structures
  • Year:
  • 2013

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Abstract

Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.