Automatic 4-D registration in dynamic MR renography based on over-complete dyadic wavelet and fourier transforms

  • Authors:
  • Ting Song;Vivian S. Lee;Henry Rusinek;Manmeen Kaur;Andrew F. Laine

  • Affiliations:
  • Department of Biomedical Engineering, Columbia University, New York, NY;Department of Radiology, New York University School of Medicine, New York, NY;Department of Radiology, New York University School of Medicine, New York, NY;Department of Radiology, New York University School of Medicine, New York, NY;Department of Biomedical Engineering, Columbia University, New York, NY

  • Venue:
  • MICCAI'05 Proceedings of the 8th international conference on Medical image computing and computer-assisted intervention - Volume Part II
  • Year:
  • 2005

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Abstract

Dynamic contrast-enhanced 4-D MR renography has the potential for broad clinical applications, but suffers from respiratory motion that limits analysis and interpretation. Since each examination yields at least over 10-20 serial 3-D images of the abdomen, manual registration is prohibitively laborintensive. Besides in-plane motion and translation, out-of-plane motion and rotation are observed in the image series. In this paper, a novel robust and automated technique for removing out-of-plane translation and rotation with sub-voxel accuracy in 4-D dynamic MR images is presented. The method was evaluated on simulated motion data derived directly from a clinical patient's data. The method was also tested on 24 clinical patient kidney data sets. Registration results were compared with a mutual information method, in which differences between manually co-registered time-intensity curves and tested time-intensity curves were compared. Evaluation results showed that our method agreed well with these ground truth data.