Identifying Relevant Data for a Biological Database: Handcrafted Rules versus Machine Learning

Authors:
Aditya Kumar Sehgal;Sanmay Das;Keith Noto;Milton Saier;Charles Elkan
Affiliations:
Parity Computing, La Jolla;Rensselaer Polytechnic Institute, Troy;University of California at San Diego, La Jolla;University of California at San Diego, La Jolla;University of California at San Diego, La Jolla
Venue:
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Year:
2011

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Using multiple sensors for reliable markerless identification through supervised learning

Machine Vision and Applications

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Abstract

With well over 1,000 specialized biological databases in use today, the task of automatically identifying novel, relevant data for such databases is increasingly important. In this paper, we describe practical machine learning approaches for identifying MEDLINE documents and Swiss-Prot/TrEMBL protein records, for incorporation into a specialized biological database of transport proteins named TCDB. We show that both learning approaches outperform rules created by hand by a human expert. As one of the first case studies involving two different approaches to updating a deployed database, both the methods compared and the results will be of interest to curators of many specialized databases.