Ion channel modeling with analog circuit evolution

Authors:
Theodore W. Cornforth;Jim Torresen;Hod Lipson
Affiliations:
Cornell University, Ithaca, NY, USA;University of Oslo, Oslo, Norway;Cornell University, Ithaca, NY, USA
Venue:
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation
Year:
2011

Citing 3
Cited 0

Evolution of analog circuit models of ion channels

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Automated synthesis of analog electrical circuits by means ofgenetic programming

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A fast and elitist multiobjective genetic algorithm: NSGA-II

IEEE Transactions on Evolutionary Computation

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Abstract

We propose that analog electrical circuits are a natural representation for modeling the dynamical systems that arise in neuroscience. Here we use analog circuit evolution, a reverse engineering technique designed to search through analog circuit space, to automatically design circuit models of ion channel behavior. Results comparing several different multiobjective and coevolutionary techniques demonstrate the importance of evaluating the fitness of evolved circuits under multiple behavioral conditions.