From pathways to biomolecular events: opportunities and challenges

  • Authors:
  • Tomoko Ohta;Sampo Pyysalo;Jun'ichi Tsujii

  • Affiliations:
  • University of Tokyo, Tokyo, Japan;University of Tokyo, Tokyo, Japan;Microsoft Research Asia, Beijing, China

  • Venue:
  • BioNLP '11 Proceedings of BioNLP 2011 Workshop
  • Year:
  • 2011

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Abstract

The construction of pathways is a major focus of present-day biology. Typical pathways involve large numbers of entities of various types whose associations are represented as reactions involving arbitrary numbers of reactants, outputs and modifiers. Until recently, few information extraction approaches were capable of resolving the level of detail in text required to support the annotation of such pathway representations. We argue that event representations of the type popularized by the BioNLP Shared Task are potentially applicable for pathway annotation support. As a step toward realizing this possibility, we study the mapping from a formal pathway representation to the event representation in order to identify remaining challenges in event extraction for pathway annotation support. Following initial analysis, we present a detailed study of protein association and dissociation reactions, proposing a new event class and representation for the latter and, as a step toward its automatic extraction, introduce a manually annotated resource incorporating the type among a total of nearly 1300 annotated event instances. As a further practical contribution, we introduce the first pathway-to-event conversion software for SBML/CellDesigner pathways and discuss the opportunities arising from the ability to convert the substantial existing pathway resources to events.