Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis

  • Authors:
  • Salvador Tortajada;Elies Fuster-Garcia;Javier Vicente;Pieter Wesseling;Franklyn A. Howe;Margarida Julií-Sapé;Ana-Paula Candiota;Daniel Monleón;íngel Moreno-Torres;Jesús Pujol;John R. Griffiths;Alan Wright;Andrew C. Peet;M. Carmen Martínez-Bisbal;Bernardo Celda;Carles Arús;Montserrat Robles;Juan Miguel García-Gómez

  • Affiliations:
  • IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, València, Spain;IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, València, Spain;IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, València, Spain;Dept. of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;Cardiac and Vascular Sciences, St. George's University of London, London, UK;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Dept. de Bioquímica i Biologia Molecular, Universitat Autòno ...;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Dept. de Bioquímica i Biologia Molecular, Universitat Autòno ...;Fundación Investigación Hospital Clínico Valencia /INCLIVA, Valencia, Spain;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Research Dept., Centre Diagnòstic Pedralbes, Esplugues de Llobreg ...;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and CRC Corporació Sanitíria, Institut d'Alta Tecnologia - PRBB, ...;CR UK Cambridge Research Institute, Cambridge, UK;Dept. of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;University of Birmingham and Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Dept. Química Física, Universitat de València, Valè ...;Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain and Dept. de Bioquímica i Biologia Molecular, Universitat Autòno ...;IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, València, Spain;IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, València, Spain

  • Venue:
  • Journal of Biomedical Informatics
  • Year:
  • 2011

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Abstract

In the last decade, machine learning (ML) techniques have been used for developing classifiers for automatic brain tumour diagnosis. However, the development of these ML models rely on a unique training set and learning stops once this set has been processed. Training these classifiers requires a representative amount of data, but the gathering, preprocess, and validation of samples is expensive and time-consuming. Therefore, for a classical, non-incremental approach to ML, it is necessary to wait long enough to collect all the required data. In contrast, an incremental learning approach may allow us to build an initial classifier with a smaller number of samples and update it incrementally when new data are collected. In this study, an incremental learning algorithm for Gaussian Discriminant Analysis (iGDA) based on the Graybill and Deal weighted combination of estimators is introduced. Each time a new set of data becomes available, a new estimation is carried out and a combination with a previous estimation is performed. iGDA does not require access to the previously used data and is able to include new classes that were not in the original analysis, thus allowing the customization of the models to the distribution of data at a particular clinical center. An evaluation using five benchmark databases has been used to evaluate the behaviour of the iGDA algorithm in terms of stability-plasticity, class inclusion and order effect. Finally, the iGDA algorithm has been applied to automatic brain tumour classification with magnetic resonance spectroscopy, and compared with two state-of-the-art incremental algorithms. The empirical results obtained show the ability of the algorithm to learn in an incremental fashion, improving the performance of the models when new information is available, and converging in the course of time. Furthermore, the algorithm shows a negligible instance and concept order effect, avoiding the bias that such effects could introduce.