Sum Versus Vote Fusion in Multiple Classifier Systems
IEEE Transactions on Pattern Analysis and Machine Intelligence
Journal of Cognitive Neuroscience
Robust atlas-based segmentation of highly variable anatomy: left atrium segmentation
STACOM'10/CESC'10 Proceedings of the First international conference on Statistical atlases and computational models of the heart, and international conference on Cardiac electrophysiological simulation challenge
IPMI'13 Proceedings of the 23rd international conference on Information Processing in Medical Imaging
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Segmentation of medical images has become critical to building understanding of biological structure-functional relationships. Atlas registration and label transfer provide a fully-automated approach for deriving segmentations given atlas training data. When multiple atlases are used, statistical label fusion techniques have been shown to dramatically improve segmentation accuracy. However, these techniques have had limited success with complex structures and atlases with varying similarity to the target data. Previous approaches have parameterized raters by a single confusion matrix, so that spatially varying performance for a single rater is neglected. Herein, we reformulate the statistical fusion model to describe raters by regional confusion matrices so that coregistered atlas labels can be fused in an optimal, spatially varying manner, which leads to an improved label fusion estimation with heterogeneous atlases. The advantages of this approach are characterized in a simulation and an empirical whole-brain labeling task.