Toward elucidation of longevity of immunological memory

Authors:
Kouji Harada;Yoshiteru Ishida
Affiliations:
Toyohasi University of Technology, Aichi, Japan;Toyohasi University of Technology, Aichi, Japan
Venue:
KES'11 Proceedings of the 15th international conference on Knowledge-based and intelligent information and engineering systems - Volume Part IV
Year:
2011

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Abstract

An interesting and substantial feature of the immune memory is its eventual loss, namely "longevity". An extension of longevity is a significant issue for efficacy of vaccines. We have discussed possible mechanisms of an immune memory with longevity from a dynamical viewpoint, and demonstrated that a particular transient dynamics was promising for reproducing an immune memory with longevity. The present paper analytically derives an equation to estimate the longevity and clarifies a dependency relationship between system parameters and longevity of an immune memory. Finally it confirms validity of the relationship from an immunological viewpoint.