Emergence of immune memory and tolerance in an asymmetric idiotype network
KES'05 Proceedings of the 9th international conference on Knowledge-Based Intelligent Information and Engineering Systems - Volume Part II
Toward elucidation of longevity of immunological memory
KES'11 Proceedings of the 15th international conference on Knowledge-based and intelligent information and engineering systems - Volume Part IV
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Physiological experiments demonstrate establishment of immunological tolerance is controlled by dose-timing and dose-amount of an antigen. My previous study reproduced the tolerance dependent on dose-timing of an antigen in a two Bcell clones network model with an “asymmetric” Bcell-Bcell interaction. This study first clarifies its mechanism using a dynamical system technique:nullcline analysis. Next, this study proposes a three Bcell clones network model with the same style of Bcell-Bcell interaction, and shows the model simulation can reproduce the tolerance dependent on dose-amount of an antigen: high and low zone tolerance. The success of this reproduction is worthy of attention. Because theoretical studies based on the traditional “symmetric” immune network modeling scheme have not been able to reproduce it well. This study would teach us the renewed recognition of “asymmetric” immune network modeling scheme.