Time-varying procedures for insulin-dependent diabetes mellitus control

Authors:
R. S. Sánchez Peña;A. S. Ghersin;F. D. Bianchi
Affiliations:
CONICET and Center of Systems and Control, Department of Mathematics, Buenos Aires Institute of Technology, Argentina;CONICET and Department of Electrical Engineering, ITBA, Argentina;Catalonia Institute for Energy Research, Barcelona, Spain
Venue:
Journal of Electrical and Computer Engineering - Special issue on Electrical and Computer Technology for Effective Diabetes Management and Treatment
Year:
2011

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Abstract

This work considers the problem of automatically controlling the glucose level in insulin dependent diabetes mellitus (IDDM) patients. The objective is to include several important and practical issues in the design: model uncertainty, time variations, nonlinearities, measurement noise, actuator delay and saturation, and real time implementation. These are fundamental issues to be solved in a device implementing this control. Two time-varying control procedures have been proposed which take into consideration all of them: linear parameter varying (LPV) and unfalsified control (UC). The controllers are implemented with low-order dynamics that adapt continuously according to the glucose levels measured in real time in one case (LPV) and by controller switching based on the actual performance in the other case (UC). Both controllers have performed adequately under all these practical restrictions, and a discussion on pros and cons of each method is presented at the end.