Towards intra-operative prostate brachytherapy dosimetry based on partial seed localization in ultrasound and registration to C-arm fluoroscopy

Authors:
Mehdi Moradi;S. Sara Mahdavi;Sanchit Deshmukh;Julio Lobo;Ehsan Dehghan;Gabor Fichtinger;William J. Morris;Septimiu E. Salcudean
Affiliations:
Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada;Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada;Indian Institute of Technology, Bombay, India;Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada;School of Computing, Queen's University, Kingston, ON, Canada;School of Computing, Queen's University, Kingston, ON, Canada;British Columbia Cancer Agency;Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada
Venue:
MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part I
Year:
2011

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Abstract

Intraoperative dosimetry during prostate brachytherapy is a long standing clinical problem. We propose a novel framework to address this problem by reliable detection of a subset of seeds from 3D transrectal ultrasound and registration to fluoroscopy. Seed detection in ultrasound is achieved through template matching in the RF ultrasound domain followed by thresholding and spatial filtering based on the fixed distance between stranded seeds. This subset of seeds is registered to the complete reconstruction of the implant in C-arm fluoroscopy. We report results, validated with a leave-one-needle-out approach, both in a phantom (average post-registration seed distance of 2.5 mm) and in three clinical patient datasets (average error: 3.9 mm over 113 seeds).