Introduction to statistical pattern recognition (2nd ed.)
Introduction to statistical pattern recognition (2nd ed.)
Editorial: Hybrid learning machines
Neurocomputing
Editorial: Hybrid intelligent algorithms and applications
Information Sciences: an International Journal
Skewness as feature for the diagnosis of Alzheimer's disease using spect images
ICIP'09 Proceedings of the 16th IEEE international conference on Image processing
GMM based SPECT image classification for the diagnosis of Alzheimer's disease
Applied Soft Computing
Projection pursuit mixture density estimation
IEEE Transactions on Signal Processing
Unsupervised image-set clustering using an information theoretic framework
IEEE Transactions on Image Processing
On the empirical mode decomposition applied to the analysis of brain SPECT images
Expert Systems with Applications: An International Journal
Early diagnosis of Alzheimer's disease based on Partial Least Squares and Support Vector Machine
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
LVQ-SVM based CAD tool applied to structural MRI for the diagnosis of the Alzheimer's disease
Pattern Recognition Letters
An analysis of unit tests of a flight software product line
Science of Computer Programming
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Several approaches appear in literature in order to develop Computed-Aided-Diagnosis (CAD) systems for Alzheimer's disease (AD) detection. Although univariate models became very popular and nowadays they are widely used, recent investigations are focused on multivariate models which deal with a whole image as an observation. In this work, we compare two multivariate approaches that use different methodologies to relieve the small sample size problem. One of them is based on Gaussian Mixture Model (GMM) and models the Regions of Interests (ROIs) defined as differences between controls and AD subject. After GMM estimation using the EM algorithm, feature vectors are extracted for each image depending on the positions of the resulting Gaussians. The other method under study computes score vectors through a Partial Least Squares (PLS) algorithm based estimation and those vectors are used as features. Before extracting the score vectors, a binary mask based dimensional reduction of the input space is performed in order to remove low-intensity voxels. The validity of both methods is tested on the ADNI database by implementing several CAD systems with linear and nonlinear classifiers and comparing them with previous approaches such as VAF and PCA.