Machine Learning
Estimating generalization error using out-of-bag estimates
AAAI '99/IAAI '99 Proceedings of the sixteenth national conference on Artificial intelligence and the eleventh Innovative applications of artificial intelligence conference innovative applications of artificial intelligence
Computer-Assisted Research Design and Analysis
Computer-Assisted Research Design and Analysis
Machine Learning
Classification of SPECT Images of Normal Subjects versus Images of Alzheimer's Disease Patients
MICCAI '01 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention
Journal of Cognitive Neuroscience
IWANN '09 Proceedings of the 10th International Work-Conference on Artificial Neural Networks: Part I: Bio-Inspired Systems: Computational and Ambient Intelligence
GMM based SPECT image classification for the diagnosis of Alzheimer's disease
Applied Soft Computing
Overview and recent advances in partial least squares
SLSFS'05 Proceedings of the 2005 international conference on Subspace, Latent Structure and Feature Selection
Hi-index | 12.05 |
An accurate and early diagnosis of the Alzheimer's disease (AD) is of fundamental importance for the patient medical treatment. It has been shown that pathological manifestations of AD may be detected thought functional images even before that the patients becomes symptomatic. This fact has led researchers to propose new ways for analyzing functional data in order to get more accurate Computer-Aided Diagnosis (CAD) systems for this disorder. In this paper we show an effective approach for Single Photon Emission Computed Tomography feature extraction that improves the accuracy of CAD systems for AD. The proposed methodology uses a Partial Least Squares algorithm for extracting score vectors and the Out-Of-Bag error for selecting a number of scores that are used as features. Subsequently, a Support Vector Machine (SVM) based classifier determines the underlying class of the images, thus performing diagnostics. In order to test this approach we have used an image database for AD with 97 SPECT images from controls and AD patients. The images were visually labeled by experienced clinicians after the properly normalization. Several experiments have been developed to compare the proposed methodology and previous approaches. The results show that our method yields accuracy rates over 90%, outperforming several recently reported CAD systems for AD diagnosis.