Photo- and thermoregulation of DNA nanomachines

Authors:
Keiichiro Takahashi;Satsuki Yaegashi;Hiroyuki Asanuma;Masami Hagiya
Affiliations:
NovusGene Inc., Tokyo, Japan;Japan Science and Technology Corporation (JST-CREST);Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya, Japan;Japan Science and Technology Corporation (JST-CREST)
Venue:
DNA'05 Proceedings of the 11th international conference on DNA Computing
Year:
2005

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Abstract

We have been investigating DNA state machines, especially those based on the opening of hairpin molecules in which state transitions are realized as hairpin loops are opened by molecules called openers. This paper introduces photo- and thermoregulation of such hairpin-based DNA machines, in which the openers become active by sensing external signals in the form of light or heat. We conducted fluorescence experiments and show that photo- and thermoregulation is possible. In the experiments, the openers become active when they are irradiated by UV light or when they receive heat as external input. For photoregulation, we use azobenzene-bearing oligonucleotides developed by the third author.