Using DNA to Power Nanostructures

Authors:
Bernard Yurke;Allen P. Mills, Jr.
Affiliations:
Bell Laboratories, Lucent Technologies, Murray Hill, NJ, 07974;Department of Physics, University of California, Riverside, CA, 92521-0208
Venue:
Genetic Programming and Evolvable Machines
Year:
2003

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Abstract

DNA hybridization has been used to power a number of DNA-based nanostructures constructed out of DNA. Here some considerations that go into DNA-based motor design are briefly reviewed. The emphasis will be on the operation of toeholds, single-stranded sections of DNA that facilitate the process of strand removal during certain points in the operation of a DNA-based motor. Reaction kinetics measurements for toehold mediated strand exchange are reported. These measurements have served as a guide for choosing toehold lengths.