3D curve inference for diffusion MRI regularization

  • Authors:
  • Peter Savadjiev;Jennifer S. W. Campbell;G. Bruce Pike;Kaleem Siddiqi

  • Affiliations:
  • School of Computer Science & Centre For Intelligent Machines, McGill University, Montréal, QC, Canada;McConnell Brain Imaging Centre, Montréal Neurological Institute;McConnell Brain Imaging Centre, Montréal Neurological Institute;School of Computer Science & Centre For Intelligent Machines, McGill University, Montréal, QC, Canada

  • Venue:
  • MICCAI'05 Proceedings of the 8th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
  • Year:
  • 2005

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Abstract

We develop a differential geometric framework for regularizing diffusion MRI data. The key idea is to model white matter fibers as 3D space curves and to then extend Parent and Zucker’s 2D curve inference approach [8] by using a notion of co-helicity to indicate compatibility between fibre orientation estimates at each voxel with those in a local neighborhood. We argue that this provides several advantages over earlier regularization methods. We validate the approach quantitatively on a biological phantom and on synthetic data, and qualitatively on data acquired in vivo from a human brain.