Pattern Recognition
Tracking Deformable Objects in the Plane Using an Active Contour Model
IEEE Transactions on Pattern Analysis and Machine Intelligence
Cell Segmentation with Median Filter and Mathematical Morphology Operation
ICIAP '99 Proceedings of the 10th International Conference on Image Analysis and Processing
A neural classifier enabling high-throughput topological analysis of lymphocytes in tissue sections
IEEE Transactions on Information Technology in Biomedicine
Coupled Minimum-Cost Flow Cell Tracking
IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
Tracking cell motion using GM-PHD
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Mitosis sequence detection using hidden conditional random fields
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Understanding the optics to aid microscopy image segmentation
MICCAI'10 Proceedings of the 13th international conference on Medical image computing and computer-assisted intervention: Part I
On tree-constrained matchings and generalizations
ICALP'11 Proceedings of the 38th international colloquim conference on Automata, languages and programming - Volume Part I
MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part I
Optical flow based arabidopsis thaliana root meristem cell division detection
ICIAR'10 Proceedings of the 7th international conference on Image Analysis and Recognition - Volume Part II
Pipeline for tracking neural progenitor cells
MCV'12 Proceedings of the Second international conference on Medical Computer Vision: recognition techniques and applications in medical imaging
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The Large Scale Digital Cell Analysis System (LSDCAS) developed at the University of Iowa provides capabilities for extended-time live cell image acquisition. This paper presents a new approach to quantitative analysis of live cell image data. By using time as an extra dimension, level set methods are employed to determine cell trajectories from 2D + time data sets. When identifying the cell trajectories, cell cluster separation and mitotic cell detection steps are performed. Each of the trajectories corresponds to the motion pattern of an individual cell in the data set. At each time frame, number of cells, cell locations, cell borders, cell areas, and cell states are determined and recorded. The proposed method can help solving cell analysis problems of general importance including cell pedigree analysis and cell tracking. The developed method was tested on cancer cell image sequences and its performance compared with manually-defined ground truth. The similarity Kappa Index is 0.84 for segmentation area and the signed border positioning segmentation error is 1.6 ± 2.1 μm.