On mobility analysis of functional sites from time lapse microscopic image sequences of living cell nucleus

Authors:
Lopamudra Mukherjee;Vikas Singh;Jinhui Xu;Kishore S. Malyavantham;Ronald Berezney
Affiliations:
Department of Computer Science and Engineering, State University of New York at Buffalo;Department of Computer Science and Engineering, State University of New York at Buffalo;Department of Computer Science and Engineering, State University of New York at Buffalo;Department of Biological Sciences, State University of New York at Buffalo;Department of Biological Sciences, State University of New York at Buffalo
Venue:
MICCAI'06 Proceedings of the 9th international conference on Medical Image Computing and Computer-Assisted Intervention - Volume Part II
Year:
2006

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Abstract

Recent research in biology has indicated correlations between the movement patterns of functional sites (such as replication sites in DNA) and zones of genetic activity within a nucleus. A detailed study and analysis of the motion dynamics of these sites can reveal an interesting insight into their role in DNA replication and function. In this paper, we propose a suite of novel techniques to determine, analyze, and interpret the mobility patterns of functional sites. Our algorithms are based on interesting ideas from theoretical computer science and database theory and provide for the first time the tools to interpret the seemingly stochastic motion patterns of the functional sites within the nucleus in terms of a set of tractable ‘patterns’ which can then be analyzed to understand their biological significance.