RECOMB '00 Proceedings of the fourth annual international conference on Computational molecular biology
Evolutionary modeling and inference of gene network
Information Sciences—Informatics and Computer Science: An International Journal - Bioinformatics-selected papers from 4th CBGI & 6th JCIS Proceedings
A Fast Elitist Non-dominated Sorting Genetic Algorithm for Multi-objective Optimisation: NSGA-II
PPSN VI Proceedings of the 6th International Conference on Parallel Problem Solving from Nature
Combining Microarrays and Biological Knowledge for Estimating Gene Networks via Bayesian Networks
CSB '03 Proceedings of the IEEE Computer Society Conference on Bioinformatics
Multiobjective Optimization in Bioinformatics and Computational Biology
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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With the invention of microarray technology, researchers are able to measure the expression levels of ten thousands of genes in parallel at various time points of a biological process. The investigation of gene regulatory networks has become one of the major topics in Systems Biology. In this paper we address the problem of finding gene regulatory networks from experimental DNA microarray data. We suggest to use a multi-objective evolutionary algorithm to identify the parameters of a non-linear system given by the observed data. Currently, only limited information on gene regulatory pathways is available in Systems Biology. Not only the actual parameters of the examined system are unknown, also the connectivity of the components is a priori not known. However, this number is crucial for the inference process. Therefore, we propose a method, which uses the connectivity as an optimization objective in addition to the data dissimilarity (relative standard error - RSE) between experimental and simulated data.