Applications of 'TissueQuant'- A color intensity quantification tool for medical research

  • Authors:

  • Keerthana Prasad;Bhagath Kumar P.;Marx Chakravarthy;Gopalakrishna Prabhu

  • Affiliations:

  • Manipal Centre for Information Science, Manipal University, Manipal 576104, India;Faculty of Medical Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia;Anatomy Department, Kasturba Medical College, Manipal University, Manipal 576104, India and College of Medicine, American University of Antigua, Antigua, West Indies;Biomedical Engineering Department, Manipal Institute of Technology, Manipal 576104, India

  • Venue:
  • Computer Methods and Programs in Biomedicine
  • Year:
  • 2012

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Abstract

This paper demonstrates the use of TissueQuant - an image analysis tool for quantification of color intensities which was developed for use in medical research where the stained biological specimen such as tissue or antigen needs to be quantified. TissueQuant provides facilities for user interaction to choose and quantify the color of interest and its shades. Gaussian weighting functions are used to provide a color score which quantifies how close the shade is to the user specified reference color. We describe two studies in medical research which use TissueQuant for quantification. The first study evaluated the effect of petroleum-ether extract of Cissus quadrangularis (CQ) on osteoporotic rats. It was found that the analysis results correlated well with the manual evaluation, p